Hyaluronic acid (HA), is a natural product that is most often taken from the comb of a rooster. It is a high molecular weight polysaccharide widely distributed in the extracellular matrix of connective tissue. Due to hyaluronic acid’s highly anionic proprieties, it can attract water to swell, create volume, provide structural support, lubricate joints, and help stimulate the repair of the discs in the spine. HA can increase collagen production as well. For the joints, it is a naturally occurring component of the synovial fluid and cartilage. In osteoarthritis, the concentration of hyaluronic acid decreases, along with a reduction in the size of individual hyaluronic acid molecules, thus decreasing the viscosity of the synovial fluid. Lastly, HA and its binding proteins regulate the expression of genes that cause inflammation. Lastly, HA and its binding proteins regulate the expression of genes that cause inflammation.