Hyaluronic acid – HA, is a natural product that is most often taken from the comb of a rooster. It is a high-molecular-weight polysaccharide that is widely distributed in the connective tissue extracellular matrix. Due to hyaluronic acid’s highly anionic proprieties, it can attract water to swell and create volume and provide structural support and lubricate joints and help stimulate repair of the discs in the spine. HA can increase collagen production as well. For the joints, it is a naturally occurring part of the synovial fluid and cartilage, and in osteoarthritis, the concentration of hyaluronic acid decreases along with a decrease in the size of individual hyaluronic acid molecules, thus decreasing the viscosity of the synovial fluid. Lastly, HA and its binding proteins regulate the expression of genes that cause inflammation.